Sterile and non sterile compounding options – At a glance

In general, compounding pharmacy equipment consists of a wide variety of barrier isolators, clean benches and NSF-listed biological safety cabinets.

The Pharmacy Compounding Aseptic Containment Isolator is the premium solution product within the pharmacy compounding category. It provides a clean and safe atmosphere for compounding non-hazardous, sterile drug preparations in accordance with the criteria set by USP 797. The following are the key benefits of a Pharmacy Compounding Aseptic Containment Isolator: Superior operator protection, ISO Class 3 work zone, motorized adjustable height stand, fast purging time and USP 797 compliant.

The barrier isolation system offers a superior sterility compared to any open front clean air equipment like Class II biosafety cabinets and laminar flow clean benches. Furthermore, the USP797 guidelines indicate that isolators may be well-suited for installation in areas subject to less critical environmental controls compared with open front clean air devices.read more

Additionally, when it is used as part of a system consisting of operator aseptic technique training, expiration setting, process validation, and product quality maintenance after the CSP leaves the pharmacy; an isolator can be a very lucrative solution particularly for some lower-volume pharmacies. It can basically cut down operating, as well as, renovation costs.

Similarly, Compounding Aseptic Containment Isolator (Recirculating) models occupy a small space and are easy to maintain. A recirculating model should be used for jobs involving hazardous materials, cytotoxic or antineoplastic compounding applications. The work zones, as well as the pass through interchange, are under negative pressure to the room to maintain operator protection and sterility in case the barrier isolation system is compromised.

Below are some good laboratory practices that you may want to take note of whether using a barrier isolation system or not.

1. Use proper hand washing along with a gowning technique to reduce bacterial contamination.
2. Use wipers and mops that are made of polyester knit fabrics for cleaning and disinfecting, as they don’t normally shed particulates.
3. Wipe thoroughly in a single direction from the cleanest to the slightly clean areas.
4. Don’t perform any cleaning, sanitizing or sterilizing while compounding activities are still in progress.